JD.com is headquartered in Beijing, with warehouses in seven major inventory logistics centers in Beijing, Shanghai, Guangzhou, Shenyang, Xi'an, Wuhan, and Chengdu. According to the 2017 fiscal year performance report released by JD.com on March 2, as of December 31, 2017, JD.com operated 486 large warehouses in China, with a total area of ​​about 10 million square meters. The number of large warehouses operated by JD Logistics increased from 256 at the end of 2016 to 486 at the end of 2017, and the total area increased from 5.6 million square meters to 10 million square meters. Among them, "Asia No. 1", the largest and most automated modern logistics center in Asia, was expanded to 11 during the 2017 Double Eleven period.

In terms of overseas layout, in the Indonesian market, JD.com has set up warehouses in 4 cities, and its delivery services have covered 7 major islands, 483 cities and 6,500 districts and counties. The product categories cover 19 categories and 127 sub-categories such as 3C, home appliances, fashion, and luxury goods. In Thailand, JD.com Group and Central Group, the largest retail company in Thailand, have established a joint venture in Thailand to provide e-commerce services and financial technology services to the local area, and launched a new online retail platform for Thailand and the entire Southeast Asia. JD.com Group also jointly invested in the Vietnamese e-commerce platform Tiki with VNG Company and became one of Tiki's major shareholders. In addition to the business expansion in the United States, Russia, the United Kingdom, Australia and other countries, JD.com has initially built a cross-border e-commerce and cross-border logistics system. Thousands of Chinese companies have signed letters of intent to "go overseas" with JD.com, and will enter the global market through the promotion of JD.com's "sell globally" business.